3-in-1 Regeneration NAD+ 500mg + Resveratrol + Quercetin Capsules
$34.50 USD
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AM | REGENERATE
3-in-1 Regeneration NAD+ 500mg + Resveratrol + Quercetin Capsules
Our advanced NAD+ nutrient combination contains pure botanical extracts to support healthy cellular energy production and overall vitality.
Resveratrol (an antioxidant from Japanese Knotweed extract) is known for its role in supporting cardiovascular health and promoting cellular wellness.
Quercetin (an antioxidant from whole flower bud extract) helps to support a healthy inflammatory response and contributes to optimal immune function.
Verified potency. Clean-label. Science-informed. cGMP facility.
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$34.50 USD
60 capsules | 30-days supply
Result*
Energy - Helps to experience a consistent, high-level ceiling of energy all day.
Brain - Supports improved alertness and memory recall, sustained focus, decreased afternoon crash.
Mood - Encourages increased mood stability and stress management, less irritability.
Physical - Supports increased strength and reduced muscle soreness.
Skin - Supports increased collagen support and DNA repair for smoother skin.
Rest - NAD+ helps to regulate your circadian rhythm to fall asleep faster and wake refreshed.
Ingredients
- NAD (Nicotinamide Adenine Dinucleotide)
- Quercetin (Sophora Japonica)(whole flower bud)
- Japanese Knotwood Extract (98% resveratrol)(Polygonum cuspidatum)
- HPMC
- MCC
- Brown rice flour
- Olive oil
- Silicon Dioxide
- Magnesium Stearate
Verified Potency
Every formulation carries a Certificate of Analysis (COA) to verify product content and quality.
We use globally-sourced ingredients formulated in FDA-registered, GMP-certified facilities in the USA.
We formulate nutrient systems to support your connected biology.
Feel and function at your best - consistently.
Precision-Formulated | Science-Informed
Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme found in every cell, essential for cellular energy production and metabolic function. NAD⁺ levels naturally decline with age, which has led to growing scientific interest in nutritional strategies that support NAD⁺-dependent pathways.
Polyphenols and NAD⁺-Dependent Pathways
Polyphenols such as resveratrol and quercetin have been widely studied for their interaction with cellular pathways linked to NAD⁺ metabolism.
Together, these compounds are of interest for their complementary roles in supporting cellular processes associated with NAD⁺ availability and utilization.
Mechanistic Insights from Research
Preclinical and early-stage research suggests that
These mechanisms are part of a broader network of biological processes involved in maintaining cellular function.
Polyphenols can interact with broader metabolic regulators such as AMPK, which are closely linked to cellular energy balance
Dosage Considerations
Scientific studies investigating resveratrol and quercetin have used a wide range of intake levels. Supplemental amounts commonly explored in human research often fall within the range of:
There is currently no universally established optimal dosage for supporting NAD⁺ metabolism, and responses may vary depending on individual physiology and overall health status.
RESVERATROL
Resveratrol may help support NAD⁺-dependent signaling pathways through activation of sirtuins.
Resveratrol is known to influence sirtuins—particularly SIRT1 enzymes that rely on NAD⁺ to regulate cellular stress responses, mitochondrial function, and metabolic health.
Resveratrol: approximately 100–500 mg per day
QUERCETIN
Quercetin has been studied for its potential to influence NAD⁺ metabolism by modulating CD38 activity
Quercetin, a naturally occurring flavonoid, has been investigated for its role in modulating enzymes involved in NAD⁺ turnover, including CD38, one of the primary enzymes responsible for NAD⁺ degradation.
Quercetin: approximately 500–1000 mg per day
Ongoing Research
Research into NAD⁺ biology and polyphenol interactions is ongoing. While mechanistic and preclinical findings are promising, further human studies are needed to fully understand the extent of their effects in the context of daily supplementation.
Scientific Context
This information is intended to present current scientific understanding of NAD⁺-related pathways and the role of nutritional compounds. It is not intended to diagnose, treat, cure, or prevent any disease.
References
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD⁺ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119–141. doi:10.1038/s41580-020-00313-x
- Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD⁺ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016;17(11):679–690. doi:10.1038/nrm.2016.93
- Kulkarni SS, Canto C. The molecular targets of resveratrol. Biochim Biophys Acta Mol Basis Dis. 2015;1852(6):1114–1123. doi:10.1016/j.bbadis.2014.10.005
- Imai S, Guarente L. NAD⁺ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464–471. doi:10.1016/j.tcb.2014.04.002
- Chini CCS, Tarragó MG, Chini EN. NAD and the aging process: role in life, death and everything in between. Mol Cell Endocrinol. 2017;455:62–74. doi:10.1016/j.mce.2016.11.003
- Kedlaya R, Veeraiah P, Tamma V. Polyphenols and NAD⁺ metabolism: implications for health and longevity. Int J Mol Sci. 2022;23(3):1202. doi:10.3390/ijms23031202
- Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci. 2014;35(3):146–154. doi:10.1016/j.tips.2013.12.004
- Roboon J, Hattori T, Ishii H, Takarada-Iemata M, Le TM, Shiraishi Y, et al. Quercetin enhances NAD⁺ levels and sirtuin activity through CD38 inhibition. Biochem Biophys Res Commun. 2019;512(2):246–251. doi:10.1016/j.bbrc.2019.03.086
- Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J. Anti-inflammatory action and mechanisms of resveratrol. Molecules. 2021;26(1):229. doi:10.3390/molecules26010229
- Dellinger RW, Santos SR, Morris M, Evans M, Alminana D, Guarente L, Marcotulli E. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD⁺ levels in humans safely and sustainably. NPJ Aging Mech Dis. 2017;3:17. doi:10.1038/s41514-017-0016-9
OUR CAPSULE
Redefining daily vitality
Synergistic Nutrient Formulation
More than an isolated nutrient. We encapsulate nutrient combinations to support your connected biological system.
Clean-label, Bioavailable
Our capsules are designed to release nutrients where they’re best absorbed, with a fast-dissolving shell for quicker nutrient availability and no synthetic fillers to get in the way.
Designed for Consistency
We use ingredient levels consistent with those commonly studied in nutritional research.
THE SCIENCE
Nutrient intake at the times that your body clock needs it.
Your body follows a 24-hour circadian rhythm that influences energy levels, alertness, and rest cycles.
By aligning precisely-formulated nutrient combinations with these natural cycles, our Resilience Reset™ system supports consistency in how you feel and function throughout the day.
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3-in-1 Regeneration NAD+ 500mg + Resveratrol + Quercetin Capsules
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Resilience Reset 3-Step Protocol
One protocol aligned to your body clock for consistent balanced energy
REGENERATE
3-in-1 Regeneration NAD+ 500mg + Resveratrol + Quercetin Capsules
3-in-1 NAD+ Resveratrol Quercetin / Cellular Health • Foundational Vitality
REGULATE
8-in-1 Advanced KSM-66® Ashwagandha 600mg Root Extract Capsules
KSM-66 600 mg Ashwagandha Nutrient Complex / Balanced Energy
RESTORE
Pure Restoration 275mg Elemental Magnesium Glycinate Capsules
275 mg Pure Elemental Magnesium Glycinate / Relax • Sleep • Recover
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We offer a 90-day money-back guarantee. Try the protocol risk-free. Verified potency. Science-informed. Clean. Vegan.
FAQ
Our mission is intentional nutrition - science-informed, clean-label, bioavailable nutrient combinations aligned with your body’s natural biology and designed for consistency.
01. What is the Circadian Rhythm
The circadian rhythm isthe body’s internal 24-hour clock, regulating sleep-wake cycles, hormone release, metabolism, and body temperature. It acts as a "master clock" that synchronizes with environmental cues like light and darkness. It governs daily cycles of alertness, digestion, and restorative sleep, significantly impacting overall physical and mental well-being.
Disruption: Environmental disruptions—like shift work, jet lag, or screen light at night—can throw off this rhythm, causing fatigue, poor focus, and long-term health issues like obesity or mental health disorders.
02. How is your Resilience Reset system different to energy drinks or caffeine?
Nutrition timed to support the circadian rhythm (chrononutrition) works by aligning energy intake with the body’s natural metabolic peaks to improve long-term health, whereas caffeine and energy drinks provide temporary, artificial alertness that often disrupts these natural rhythms and leads to metabolic imbalances.
03. Why a 3-step protocol?
We schedule supplements designed to support the circadian rhythm at specific, scheduled times throughout the day according to your body's varying metabolic, hormonal, and digestive needs.
Aligning our supplements with your natural body clock ensures maximum nutrient absorption, reduces stomach discomfort, and provides the necessary cues for wakefulness in the morning or repair and sleep at night.
04. Who is this designed for?
Our supplements use clean ingredients to support most dietary requirements.
Anyone can benefit from nutrient supplementation aligned to the circadian rhythm to support daytime energy and overnight restoration.
05. Can I get this nutrition from food and water?
Our encapsulations contain the ingredient quantities commonly explored by scientists to be effective when taken consistently.
We provide a precise quantity of a nutrient combination as a constant - to support changing food intake and schedules, ensuring your system consistently receives the nutrients it needs without the calorific tax and digestive stress.
06. Can I still have my Matcha or coffee?
Yes, you can generally take supplements designed to support your circadian rhythm while also consuming caffeine (coffee or matcha), but timing is crucial. Caffeine acts as a stimulant that can interfere with the body's natural sleep-wake cycle, while many circadian supplements aim toimprove sleep quality or regulate that same cycle.
Taking them together without considering timing can lead to counterproductive effects, such as reduced absorption of supplements or heightened anxiety.
REFERENCES
https://www.sleepfoundation.org/nutrition/caffeine-and-sleep#:~:text=Can%20Caffeine%20Cause%20Insomnia?,restful%2C%20restorative%20night%20of%20sleep.
https://www.facebook.com/THEVITAMINSHOPPE/posts/yes-you-can-have-your-supplements-and-your-coffee-tooyou-just-need-to-know-how-t/1197360882435581/#:~:text=Yes%2C%20you%20can%20have%20your,%E2%98%95%EF%B8%8F
https://mytrime.com/blogs/news/coffee-or-tea-the-effect-of-caffeine-on-sleep-and-circadian-rhythm?srsltid=AfmBOopT1ctUDLDleu0Hxh3e7DwnVlqi3jpNvRZVQKOOXOAwEQrvPD9u#:~:text=Problems%20arise%20when%20the%20effect,B%20vitamins%20and%20vitamin%20C.
Xhttps://www.eatingwell.com/supplements-to-avoid-with-coffee-11783883#:~:text=3.,B%20Vitamins&text=%E2%80%9CAvoid%20taking%20supplements%20with%20coffee,down%20easier%20after%20a%20meal.%22
https://reviveatlmd.com/whats-less-likely-to-disrupt-your-sleep-coffee-or-matcha/#:~:text=What%20time%20you%20drink%20your,day%20essential%20for%20many%20people.
https://reviveatlmd.com/whats-less-likely-to-disrupt-your-sleep-coffee-or-matcha/#:~:text=What%20time%20you%20drink%20your,day%20essential%20for%20many%20people.
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RESILIENCE RESET
3-in-1 Regeneration NAD+ 500mg + Resveratrol + Quercetin Capsules
3-in-1 Regeneration NAD+ 500mg + Resveratrol + Quercetin Capsules
$34.50 USD